ea0084op-08-41 | Oral Session 8: Basic 2 | ETA2022
Dider-Mathon Hortense
, Stoupa Athanasia
, Kariyawasam Dulanjalee
, Ydes Sonny
, Cagnard Nicolas
, Nitschke Patrick
, Scharfmann Raphael
, Luton Dominique
, Polak Michel
, Aurore Carre
Background: Previously, we identified a novel gene, BOREALIN/CDCA8 in congenital hypothyroidism. Patients with BOREALIN mutations had thyroid dysgenesis, from asymmetric lobes to athyreosis (Carré et al. Hum Mol Genet 2017). Borealin is a major component of the Chromosomal Passenger Complex, an essential regulator of mitosis. We demonstrated a new feature of BOREALIN: involvement in the adhesion and the migration of the thyrocytes.<...